MHRA Releases Updated Guidelines for Life-Saving Adrenaline Auto-Injectors

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<p>Today marks the commencement of World Allergy Week, an annual campaign led by the <a rel="external" href="https://www.worldallergy.org/" class="govuk-link">World Allergy Organization</a>, focusing on increasing awareness regarding allergies, their management, and prevention. With over 20% of the UK population experiencing at least one allergy, adrenaline auto-injectors (AAIs) are crucial healthcare tools for those at risk of anaphylaxis and can be life-saving.</p>

<p>In the UK, AAIs include Epipens and Jext products, prescribed for individuals at risk of anaphylaxis.</p>

<p>According to <a rel="external" href="https://digital.nhs.uk/data-and-information/publications/statistical/hospital-admitted-patient-care-activity/2021-22" class="govuk-link">NHS Digital’s Hospital Episode Statistics</a>, hospital admissions for allergies and anaphylaxis in England have nearly doubled over the past two decades, reaching over 26,000 admissions in 2021-22 (up from 13,440 in 2001-02).</p>

<p>Anaphylaxis can rapidly become fatal at any age, even from substances previously deemed safe. The actions taken during an emergency can determine life or death.</p>

<p>The Commission on Human Medicines (CHM), the independent body advising the government on the safety, efficacy, and quality of healthcare products, established the <a href="https://www.gov.uk/government/publications/public-assessment-report-recommendations-to-support-the-effective-and-safe-use-of-adrenaline-auto-injectors/public-assessment-report-of-the-commission-on-human-medicines-adrenaline-auto-injector-expert-working-group-recommendations-to-support-the-effectiv" class="govuk-link">Adrenaline Auto-injector Expert Working Group</a> (AAI EWG) to offer guidance and advice aimed at informing patients, healthcare professionals, and the general public about the vital and potentially life-saving role of AAIs.</p>

<p>To support this effort, the MHRA has partnered with allergy awareness advocates to provide a clear <a rel="external" href="https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1151014/17002885_The_correct_use_of_your_Adrenaline_Auto-Injector__AAI__CC_V10.pdf" class="govuk-link">step-by-step infographic guide</a> and a <a rel="external" href="https://youtu.be/4vNR5N1-iBw" class="govuk-link">video</a> that outlines the latest guidance from the CHM’s working group regarding the safe and effective use of AAIs.</p>

<h2 id="steps-people-should-take-in-an-anaphylaxis-emergency">Steps to take during an anaphylaxis emergency</h2>

<h3 id="use-your-aai-without-delay">1. Immediately use your AAI</h3>

<ul>
  <li>Activate your AAI right away if you notice any signs of anaphylaxis.</li>
  <li>Indicators may include throat or tongue swelling, wheezing or difficulty breathing, dizziness, fatigue, and confusion.</li>
  <li>If uncertain, it is better to use it.</li>
</ul>

<h3 id="immediately-dial-999">2. Call 999 immediately</h3>

<ul>
  <li>Clearly state “anaphylaxis” (“ana-fill-axis”).</li>
</ul>

<h3 id="if-you-are-not-already-lying-down-then-do-so">3. If you’re not prone, lie down flat</h3>

<ul>
  <li>Lay flat and elevate your legs (if pregnant, position yourself on your left side). This promotes blood flow to the heart and vital organs.</li>
  <li>Remain lying down even if you start to feel better.</li>
</ul>

<h3 id="use-your-second-aai-if-you-havent-improved-after-5-minutes">4. Use your second AAI if there's no improvement after 5 minutes</h3>

<ul>
  <li>Always carry two AAIs with you.</li>
  <li>Check the expiry dates! Visit a pharmacist if you need a replacement!</li>
</ul>

<p>By being more informed, we aim to empower individuals with allergies to navigate anaphylaxis with fewer severe outcomes, even if they have never faced anaphylaxis before, and to educate those without allergies on how to assist others in need.</p>

<p><strong>Julian Beach, Deputy Director of Population Health at the MHRA commented:</strong></p>

<blockquote>
  <p>Anaphylaxis can be a frightening and uncertain experience, whether faced directly or with a loved one.</p>

  <p>AAIs are essential and can be life-saving, providing individuals experiencing anaphylaxis with critical time before emergency services arrive.</p>

  <p class="last-child">It’s vital to understand how to use AAIs and actions to take in an emergency, so I encourage everyone to review the latest guidance and download these materials to be prepared.</p>
</blockquote>

<p>The MHRA will be posting updates on its social media channels throughout the week, sharing information about AAIs and anaphylaxis, using the central awareness week hashtag, #worldallergyweek.</p>

<p><strong>Simon Williams, Chief Executive of Anaphylaxis UK stated:</strong></p>

<blockquote>
  <p>Individuals living with allergies often dread the worst outcomes, and many of the people we support experience extreme anxiety about activities such as dining out and traveling, which others may take for granted.</p>

  <p>We hope that our collaboration with the MHRA and allergy awareness advocates will enhance understanding for everyone regarding what to do during anaphylaxis.</p>

  <p class="last-child">Through education on allergies, anaphylaxis, and emergency procedures, we aspire to help individuals feel more confident in their everyday activities.</p>
</blockquote>

<p><strong>Steve Barclay, Secretary of State for Health and Social Care remarked:</strong></p>

<blockquote>
  <p>A severe allergic reaction can pose life-threatening risks. One in five individuals in the UK suffers from at least one allergy, making it essential for people to be equipped with the knowledge to protect themselves.</p>

  <p class="last-child">Adrenaline auto-injectors – also referred to as AAIs or by brand names like EpiPen – are highly effective and convenient for the immediate treatment of anaphylaxis. If prescribed one, please carry it with you at all times and ensure you are informed about the latest safety guidance – it could save your life.</p>
</blockquote>

<h2 id="find-out-more">Learn more</h2>

<p><a rel="external" href="https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1151014/17002885_The_correct_use_of_your_Adrenaline_Auto-Injector__AAI__CC_V10.pdf" class="govuk-link">Infographic: Proper use of your Adrenaline Auto-Injector</a> (AAI)</p>

<p><a rel="external" href="https://youtu.be/4vNR5N1-iBw" class="govuk-link">Video: Proper use of your Adrenaline Auto-Injector</a> (AAI)</p>

<p><a href="https://www.gov.uk/government/publications/adrenaline-auto-injectors-aais-safety-campaign/adrenaline-auto-injectors-aais" class="govuk-link">Guidance: Adrenaline Auto-Injectors (AAIs)</a></p>

<p>Follow us on Twitter: <a rel="external" href="https://twitter.com/MHRAgovuk" class="govuk-link">@MHRAgovuk</a></p>

<p>Connect with us on LinkedIn: <a rel="external" href="https://www.linkedin.com/company/164969" class="govuk-link">Medicines and Healthcare products Regulatory Agency</a></p>
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